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Monitoring of metabolic variables in children and adolescents who use atypical antipsychotics assisted at the Pereira Rossell Pediatric Hospital Center
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Keywords

Antipsychotic Agents
Child
Adolescent

How to Cite

Cabral, S., Zunino, C., Catenaccio, V., Vergara, M. J., Castellano, P., Cerdeña, E., … Speranza, N. (2025). Monitoring of metabolic variables in children and adolescents who use atypical antipsychotics assisted at the Pereira Rossell Pediatric Hospital Center. Archives of Pediatrics of Uruguay, 96(2), e209. https://doi.org/10.31134/AP.96.21

Abstract

Introduction: the consumption of psychotropic drugs, particularly antipsychotics, has been increasing globally in children and adolescents (NNA). In our country, there are few studies on the subject, but they show a high level of use of these drugs. Atypical antipsychotics are associated with metabolic alterations such as dyslipidemia, diabetes, and overweight/obesity, among others.

Objectives: describe clinical and paraclinical metabolic variables in NNA using atypical antipsychotics, admitted to moderate care wards at the Pereira Rossell Hospital Center, during the period of July - September 2022.

Methodology: an observational, cross-sectional, descriptive study was conducted, including patients aged 2-15 years. Pharmacological, anthropometric, and biochemical data were obtained. Physical activity and dietary quality were evaluated. The PSPP statistical software version 3 was used. The study was approved by the Research Ethics Committee of the Pereira Rossell Hospital Center (CHPR).

Results: fifty-three NNA were included, with a median age of 13 years. Risperidone, quetiapine, and aripiprazol were the most commonly used. Thirty percent presented overweight/obesity, 50% were sedentary, and 30% had unhealthy eating habits. Twenty-one NNA had had the recommended blood biochemichal tests used to monitor these drug users.

Conclusions: metabolic alterations were found in more than half of the included subjects. Risperidone remains the most prescribed antipsychotic in this population, with a growing use of aripiprazol. Polypharmacy persisted as a prescription problem in these patients.

https://doi.org/10.31134/AP.96.21
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