Abstract
The cellulitis-adenitis syndrome is an unusual clinical presentation of late neonatal sepsis by group B Streptococcus or Streptococcus agalactiae (GBS). It is a systemic infectious process with local manifestations, with frequent involvement of the central nervous system.
The affected region is usually the face and neck, with less common involvement of the inguinal region.
We present the clinical case of an extreme preterm newborn of 27 weeks of gestational age, who presented at one month of life with late GBS sepsis, with adenitis syndrome and cellulitis of the face. After medical and surgical treatment, she presented good evolution.
References
Rodríguez A, Telechea H, Menchaca A. Infección grave por estreptococo del grupo B en la unidad de Cuidados Intensivos Pediátricos del Centro Hospitalario Pereira Rossell entre los años 2007 y 2017. Arch Pediatr Urug 2021; 92(2):e209. doi: 10.31134/ap.92.2.2.
Puopolo K, Benitz W, Zaoutis T; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of neonates born at =35 0/7 weeks' gestation with suspected or proven early-onset bacterial sepsis. Pediatrics 2018; 142(6):e20182894. doi: 10.1542/peds.2018-2894.
Coggins S, Glaser K. Updates in late-onset sepsis: risk assessment, therapy, and outcomes. Neoreviews 2022; 23(11):738-55. doi: 10.1542/neo.23-10-e738.
Puopolo K, Lynfield R, Cummings J; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Infants at Risk for Group B Streptococcal Disease. Pediatrics 2019; 144(2):e20191881. doi: 10.1542/peds.2019-1881.
Sarrión N, Morell M, Martínez L, Centeno J, Montesinos E, Orta N. Síndrome celulitis-adenitis, una forma infrecuente de presentación de la sepsis neonatal tardía: a propósito de dos casos. Arch Argent Pediatr 2018; 116(6):769-72. doi: 10.5546/aap.2018.e769.
Blázquez D, Santiago B, Ruíz J. Celulitis-adenitis inguinal en la sepsis neonatal tardía por estreptococo del grupo B. An Pediatr (Barc) 2015; 82(6):433-41. doi: 10.1016/j.anpedi.2014.11.016.
Soler P, Monfort R, Castells L, Pagone F, Serres X, Balcells J. Síndrome de celulitis-adenitis por estreptococo del grupo B como presentación de sepsis neonatal tardía. An Pediatr (Barc) 2004; 60(1):75-9. doi: 10.1016/S1695-4033(04)78219-3.
Gleason C, Juul S. Avery: enfermedades del recién nacido. 10 ed. Barcelona: Elsevier, 2019.
Madhi S, Dangor Z. Prospects for preventing infant invasive GBS disease through maternal vaccination. Vaccine 2017; 35(35 Pt A):4457-60. doi: 10.1016/j.vaccine.2017.02.025.

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